Prolotherapy
Interest in treatments that support natural healing processes is growing in modern medicine. One of these methods is prolotherapy. Prolotherapy, which is effective in alleviating musculoskeletal pain and dysfunctions, stands out with its non-invasive nature and ability to provide long-term recovery. So, what is prolotherapy, how is it applied, and who is it suitable for? You can find all the details in this article.
What is Prolotherapy?
Prolotherapy is an injection-based treatment method applied to repair and strengthen damaged or loosened connective tissues. Generally, sugar (dextrose)-based solutions are injected into weakened ligaments or tendon-ligament structures. These solutions create a localized inflammation, encouraging the body to initiate a healing process. Consequently, the body repairs the damaged tissue and makes it more durable.
What preparations are made before prolotherapy?
Before starting prolotherapy, your doctor will conduct a detailed evaluation. The area causing pain is determined through a physical examination and, if necessary, imaging methods. Things to consider before the procedure are as follows:
- Non-steroidal anti-inflammatory drugs (NSAIDs) should be discontinued a few days before the procedure.
- Blood thinners may be temporarily discontinued (with doctor's approval).
- The area should be clean on the day of the procedure, and products like lotions should not be used.
- A light meal is recommended.
How is Prolotherapy applied?
Prolotherapy is performed under sterile conditions and usually in an outpatient clinic setting. The application steps are as follows:
- The target area is cleaned with antiseptic.
- A fine-tipped needle is used to inject dextrose solution into the damaged tissues.
- The procedure typically takes between 15-30 minutes.
After the procedure, the patient can immediately return to their daily life. However, it is recommended to refrain from strenuous exercise and physical activity for a few days.
How does prolotherapy work?
The injected dextrose causes mild inflammation in the connective tissues. This activates the body's defense mechanisms and:
- New collagen production begins,
- Connective tissue strengthens,
- The looseness or imbalance causing pain is eliminated.
Thanks to this mechanism, prolotherapy targets not just the symptoms, but the source of the problem.
What are the types of prolotherapy?
Prolotherapy can be performed with different solutions and application methods:
- Dextrose Prolotherapy: The most commonly used type. Sugar-based solutions are utilized.
- PRP (Platelet-Rich Plasma) Prolotherapy: Plasma containing growth factors obtained from the person's own blood is used.
- Ozone Prolotherapy: Aims to revitalize connective tissue through ozone gas injection.
What conditions are treated with Prolotherapy?
Prolotherapy is used in the treatment of chronic pain and for resolving connective tissue problems. The most common conditions for its application are:
- Lumbar and cervical disc herniations
- Knee and hip osteoarthritis
- Shoulder capsulitis (frozen shoulder)
- Sports injuries
- Tendon and ligament injuries
- Sacroiliac joint dysfunction
What are the Side Effects and Complications of Prolotherapy?
Prolotherapy is generally a safe method. However, as with any medical procedure, some side effects may occur:
- Pain, swelling, or bruising in the treated area
- Mild fever and fatigue
- In rare cases, infection
- Temporary muscle spasms
Side effects are usually mild and resolve on their own within a few days.
How Many Treatment Sessions Are Needed in Prolotherapy and What Are the Session Intervals?
The number and frequency of sessions may vary depending on the type and severity of the disease. The general application is as follows:
- It typically varies between 3-6 sessions.
- Sessions are generally performed at intervals of 2-4 weeks.
- After each session where pain is reduced and function is increased, a follow-up evaluation is conducted.
What are Prolotherapy Treatment Prices?
Prolotherapy prices vary depending on the city, clinic, type of injection solution used and number of sessions where the application is made. It would be best to contact your clinic directly to get price information.
What is the recovery process like after prolotherapy?
After prolotherapy, mild pain and tenderness may be experienced for the first few days. This process is part of natural healing. Pain usually subsides within 1-2 weeks, and after a few sessions, a more permanent and significant improvement is achieved.
Are there risks to Prolotherapy?
Prolotherapy is a low-risk method. It does not carry serious risks other than rare complications such as infection, allergic reaction, or improper injection. It is important that the application is performed by an experienced physician.
Who should not undergo Prolotherapy?
The following conditions may constitute a contraindication for prolotherapy:
- Pregnancy
- Active infection
- Coagulation disorder
- Immunocompromised patients
What should be the expectation for effectiveness in Prolotherapy?
Every individual's healing process is different. However, the vast majority of patients undergoing prolotherapy experience reduced pain, increased function, and improved quality of life. The effect usually becomes noticeable after the 3rd session.
Is Prolotherapy a treatment like cortisone?
No. While cortisone suppresses pain, prolotherapy provides long-term healing by repairing tissue. Unlike cortisone, prolotherapy stimulates the healing mechanism and aims to resolve chronic problems.

Medical Aesthetics
Dr. Öznur Göyce
Dr. Öznur Göyce, as a physician certified in medical aesthetics, offers personalized treatments at her clinic, including Botox, nose and lip fillers, mesotherapy, and skin rejuvenation procedures.